JCRMST

Pyogenic Liver Abscess, Brain Abscess, and Culture Negative Infective Endocarditis: A Diagnostic Challenge in a Multimorbid Patient

Jazba Yousaf
Senior House Officer, Department of Geriatric Medicine, Dudley Group of Hospitals NHS FT, Dudley UK
Atef Michael
Consultant Physician, Department of Geriatric Medicine, Dudley Group of Hospitals NHS FT, Dudley UK
Folasade Ijaola
Consultant Physician, Department of Geriatric Medicine, Dudley Group of Hospitals NHS FT, Dudley UK
Shams ud Duja
Consultant Physician, Department of Geriatric Medicine, Dudley Group of Hospitals NHS FT, Dudley UK

Abstract

We present the case of a 71-year-old male who developed pyogenic liver abscesses, multiple brain abscesses, and suspected culture negative infective endocarditis (IE). This case highlights the diagnostic complexity and therapeutic challenges encountered in the management of disseminated infections in a patient with significant comorbidities. It underscores the importance of maintaining a high clinical suspicion for IE despite negative blood cultures and inconclusive echocardiographic findings. The case is used to explore key diagnostic reasoning, antimicrobial choices, and learning points relevant to trainees.

Keywords

Infective Endocarditis, Pyogenic Liver Abscess, Brain Abscess, Culture-Negative, Sepsis, Ventriculitis, Antibiotic Therapy.

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