Leukaemia Cutis (LC) is a skin infiltration which takes place via neoplastic leukocytes. Its frequency is usually dependent on the diagnosis of primary leukaemia. It is commonly observed in acute myeloid leukaemia (AML). However, it is also rarely observed in case of chronic myeloid leukaemia (CML). Thus, for present report, a case of a patient with LC involvement, presenting MLC is considered. A 62-year-old male patient with a past history of MCL was presented to haemato-oncology department in a hospital located in Beijing, China, with painful hematoma as well as subcutaneous nodes. Laboratory, coagulation, and histopathology investigations presented thrombocytosis, leucocytosis, dissemination of intravascular coagulation, anaemia, and elevation of inflammatory markers. Aspiration of bone marrow also showed proliferation of granular lineage without any excessive blasts. This presented the option of recurrence of CML or AML progression. Moroever, skin biopsy also helped in confirming LC, presenting the myeloid-like cells’ hypodermal and dermal infiltration, without transforming AML. The immunochemistry implemented in this case, also supported the LC diagnosis. The patient was also treated with Dasatinib which also contributed to MCL recurrence. Thus, LC is stated as a rare manifestation of CML, especially outside the bone marrow of the patient. LC involvement is a rare manifestation of CML relapse. However, in present case, the presence of subcutaneous nodes on the buttock, knee, and forearms of the patient, helped in diagnosing MCL recurrence.