Pyogenic Liver Abscess, Brain Abscess, and Culture Negative Infective Endocarditis: A Diagnostic Challenge in a Multimorbid Patient

Authors

  • Jazba Yousaf Senior House Officer, Department of Geriatric Medicine, Dudley Group of Hospitals NHS FT, Dudley UK
  • Atef Michael Consultant Physician, Department of Geriatric Medicine, Dudley Group of Hospitals NHS FT, Dudley UK
  • Folasade Ijaola Consultant Physician, Department of Geriatric Medicine, Dudley Group of Hospitals NHS FT, Dudley UK
  • Shams ud Duja Consultant Physician, Department of Geriatric Medicine, Dudley Group of Hospitals NHS FT, Dudley UK

Keywords:

Infective Endocarditis, Pyogenic Liver Abscess, Brain Abscess, Culture-Negative, Sepsis, Ventriculitis, Antibiotic Therapy.

Abstract

We present the case of a 71-year-old male who developed pyogenic liver abscesses, multiple brain abscesses, and suspected culture negative infective endocarditis (IE). This case highlights the diagnostic complexity and therapeutic challenges encountered in the management of disseminated infections in a patient with significant comorbidities. It underscores the importance of maintaining a high clinical suspicion for IE despite negative blood cultures and inconclusive echocardiographic findings. The case is used to explore key diagnostic reasoning, antimicrobial choices, and learning points relevant to trainees.

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Published

2025-11-24

Issue

Vol. 1 No. 2 (2024): Volume 1 issue 2

Section

Case study